Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Currently a single accurate method for diagnosis of MS is lacking. Exosomes are small membranous transport vesicles providing a means of cell-tocell communication by transporting their cargo. Considering accumulating evidence emphasizing potential role of exosomes in the regulation of the immune system, circulating exosomes represent promising candidate biomarkers multiple sclerosis.