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Showing 2 results for Therapy
Farhad Kamandi, Mohammad Reza Emadzadeh, Saeed Ghanbari Hassan Kiadeh, Arefeh Abbasian, Seyed Amir Hossein Mohammadzadeh Hosseini Moghri ,
Volume 5, Issue 1 (5-2021)
Abstract
Background The Helicobacter pylori (H. pylori) is a spiral-shaped, gram-negative, motile and microaerophilic bacterium in which the human stomach is the single natural reservoir.
Objectives This review study indicates the possible contribution of H. pylori infection as one of the recognized vital agents for the development of gastric malignancies.
Methods Journal online databases such as Science Direct, PubMed, Google Scholar, and Wiley Online Library were investigated through keywords “Helicobacter pylori”, “Gastric Malignancy”, “Gene therapy” and “Nanotechnology”. Studies were subjected to the present review study if they met our relevance and quality criteria.
Results We will discuss different virulence elements of H. pylori comprising cytotoxin-related gene A, vacuolating cytotoxin A, as well as various outer membrane proteins leading to malignancy through various mechanisms.
Conclusions We also provide insight into the possible presence and role of a gastric malignancy stem cell in the tumors with the capability to initiate sustain self-renewal and tumor growth and novel strategies against H. pylori such as gene therapy, immunotherapy, immunoinformatics, antibiotic resistance, and nanotechnology aimed to provide a rationale view for new therapeutic approaches that are reviewed in the current study.
Marjan Behfar, Flora Forouzesh,
Volume 6, Issue 1 (5-2022)
Abstract
Background: Cytokine storm is an aberrant response from the host immune system, and a main responsibility for the incidence of acute respiratory distress syndrome. The existence of the virus induced cytokine has been linked to mortality in patients with COVID-19. The study was aimed to review the genes that role in cytokine storm as therapeutic targets in patients with COVID-19.
We demonstrated the role of pro-inflammatory cytokines in conditions that are often associated with COVID-19. Hyperproduction of mostly pro-inflammatory cytokines such as, IFN-γ, IL-6, IL-1, TNF-α, and Chemokines, which target lung tissue preferentially, can significantly worsen the prognosis in almost all cases. Data about the cytokines in this disease will support the development of more useful COVID-19 patient management strategies. In the management of COVID-19 patients, targeting cytokines can decrease mortality and increase survival rates.
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