en عمومى Human Genetics پژوهشي Research <div style="text-align: justify;"><strong>Background</strong>: Studies have shown that the polymorphism of genes involved in breast cancer in combination with environmental factors has an important role in the progression of breast cancer.<br> <strong>Objectives</strong>: In this study, the association between polymorphism of the ERBB4 gene with breast cancer was investigated.<br> <strong>Methods</strong>: In the present study, 110 patients with breast cancer and 110 healthy individuals were selected as controls. DNA extraction was performed on patients&rsquo; samples. The tetra-ARMS-PCR method was used to study rs13393577 polymorphism. Finally, statistical analysis was performed using SPSS software using t-test.<br> <strong>Results</strong>: The results of the study in the patients&rsquo; group showed that the frequencies of TT, CT, and CC genotypes were 73, 15, and 1.8%, and allelic frequency in this group for T and C alleles were 95 and 5%, respectively. In addition, the results of the study in the control group showed that the frequencies of TT, CT, and CC genotypes were 86, 11, and 0.9%, respectively. The allelic frequencies in the control group for the T and C alleles were 97 and 3%, respectively. In addition, the risk ratio and allelic reliability were obtained for T allele was OR: 3.06: and CI = 0.31 &ndash; 29.94 and for C allele was OR: 0.32: and CI: 0.03 - 3.19, respectively. Finally, statistical analysis showed that no significant difference was observed between the two groups (P > 0.05).<br> <strong>Conclusions</strong>: The results of the present study showed that rs13393577 polymorphism in the EGFR gene (ERBB4) is not a genetic predisposing factor for breast cancer.</div> 0 0 http://humangeneticsgenomics.ir/browse.php?a_code=A-10-281-1&slc_lang=en&sid=1