en عمومى Human Genetics پژوهشي Research <div style="text-align: justify;"><strong>Background</strong>: Parkinson&rsquo;s disease (PD) is one of the most common neurodegenerative diseases that cause disability. Finding treatment options that have no side effects can be very important.<br> <strong>Objectives</strong>: Therefore, in this study, the effect of &beta;-carotene administration was investigated in the PD model of rats.<br> <strong>Methods</strong>: Induction of Parkinson&rsquo;s disease in rats was done by injection of 6-hydroxydopamine (6-OHDA) into the substantia nigra (SN). After induction rat behaviour was studied using an apomorphine-induced rotation test. The SN cells&rsquo; viability was evaluated by MTT assay and apoptosis and necrosis were measured by flow cytometry. The expressions of bax and bcl-2 genes were also studied using RT-PCR technique. Data analysis was done by GraphPad Prism V.8 software.<br> <strong>Results</strong>: The results showed a positive effect of &beta;-carotene administration in PD rats, which led to improvement in apomorphineinduced rotation test, increased viability, and decreased apoptosis and necrosis of SN neurons. It also downregulated bax and overexpressed bcl-2 gene expressions (P < 0.01).<br> <strong>Conclusions</strong>: &beta;-carotene has therapeutic effects in PD conditions and its mechanism of action was attributed to regulating the expressions of genes involved in mitochondrial apoptosis. Therefore, its study in a clinical setting is recommended.</div> 0 0 http://humangeneticsgenomics.ir/browse.php?a_code=A-10-309-1&slc_lang=en&sid=1