Human Genetics and Genomics

en Genes affecting in cytokine storm as therapeutic targets in COVID-19 infection عمومى Human Genetics مروری Review Background: Cytokine storm is an aberrant response from the host immune system, and a main responsibility for the incidence of acute respiratory distress syndrome. The existence of the virus induced cytokine has been linked to mortality in patients with COVID-19. The study was aimed to review the genes that role in cytokine storm as therapeutic targets in patients with COVID-19. We demonstrated the role of pro-inflammatory cytokines in conditions that are often associated with COVID-19. Hyperproduction of mostly pro-inflammatory cytokines such as, IFN-γ, IL-6, IL-1, TNF-α, and Chemokines, which target lung tissue preferentially, can significantly worsen the prognosis in almost all cases.  Data about the cytokines in this disease will support the development of more useful COVID-19 patient management strategies. In the management of COVID-19 patients, targeting cytokines can decrease mortality and increase survival rates.   COVID-19, Cytokine storm, Therapy, Genes 0 0 http://humangeneticsgenomics.ir/browse.php?a_code=A-10-355-1&slc_lang=en&sid=1 Marjan Behfar 1003194753284600448 1003194753284600448 No MSc Genetics, Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Flora Forouzesh f8forouzesh@gmail.com 1003194753284600449 1003194753284600449 Yes Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran