Human Genetics and Genomics

en Curcumin has neuroprotective effects in rotenone-induced Parkinson disease in mice by affecting bcl-2 family gene expressions تخصصي Gene expression پژوهشي Research <div> <table align="left" hspace="0" vspace="0"> <tbody> <tr> <td style="padding: 0in 12px; text-align: justify;" valign="top">Background:  One of the common diseases in different societies is Parkinson's disease (PD), for which no suitable treatment has been found yet. Curcumin a natural compound has shown neuroprotective properties in many studies. Therefore, in this research, the administration of this compound to female mice was studied. Methods: Induction of PD in mice was done by administering 2 mg rotenone, and then a Rotarod test was performed on female mice. Also, 50 mg/kg of curcumin was administered every day for 21 days and its effects were evaluated in PD mice. Finally, the expression levels of bax and bcl-2 were measured in the brain of female mice by RT-PCR technique. GraphPad Prism V.8 software was used for data analysis. Results: Induction of PD led to a decrease in the performance of mice in the Rotarod test. However, the administration of curcumin to these mice improved their performance. Also, overexpression of bax and downregulation of bcl-2 genes were observed in the brains of PD mice, to whom the administration of curcumin downregulated bax gene and overexpressed bcl-2 gene. Conclusion: Curcumin has neuroprotective effects in PD conditions, which can be attributed to the change in expressions of the bcl-2 family gene. More studies are needed in this field.</td> </tr> </tbody> </table> </div> Gene, Curcumin, Neuroprotection, RT-PCR 0 0 http://humangeneticsgenomics.ir/browse.php?a_code=A-10-308-1&slc_lang=en&sid=1 Faramarz Khosravi faramarzkhosravi11@yahoo.com 1003194753284600436 1003194753284600436 No Ph.D student, Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran Vida Hojati vida.hojati@gmail.com 1003194753284600437 1003194753284600437 No Associate Professor, Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran. Malihe Entezari Mentezari@iautmu.ac.ir 1003194753284600438 1003194753284600438 Yes Professor, Farhikhtegan Medical Convergence sciences Research Center, Farhikhtegan Hospital Tehran Medical sciences, Islamic Azad University, Tehran, Iran. Mehrdad Hashemi mhashemi@iautmu.ac.ir 1003194753284600439 1003194753284600439 No Professor, Farhikhtegan Medical Convergence sciences Research Center, Farhikhtegan Hospital Tehran Medical sciences, Islamic Azad University, Tehran, Iran.