en تخصصي Gene expression پژوهشي Research <div> <table align="left" hspace="0" vspace="0"> <tbody> <tr> <td style="padding: 0in 12px; text-align: justify;" valign="top"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:107%"><span style="line-height:107%">The Research on the effects of magnetic fields on the expression of miRNAs is helpful to understand better the mechanism of electromagnetic fields&#39; function in the development and progression of cancer. This research investigates the effect of static magnetic fields with 1, 2, and 3 mT intensities on miR-214 expression change in the HCT-116 cell line. We used MTT assay to measure cell viability. In order to measure the expression changes of miR&ndash;214, real-time PCR was used. The results showed that the cell survival rate and expression of miR-214 had decreased significantly under the influence of magnetic fields in an intensity-dependent manner. Concerning the role of miRs in regulating signaling pathways involved in cancer promotion and progression, and their effectiveness under exposure to low-frequency magnetic fields, investigating and understanding the effects of different magnetic fields on the expression of miRs can be of great importance in preventing and controlling cancer.</span></span></span></span></td> </tr> </tbody> </table> </div> Gene Expression, miR-214, Static magnetic fields, Expression change 0 0 http://humangeneticsgenomics.ir/browse.php?a_code=A-10-358-1&slc_lang=en&sid=1 soheila Abdi abdi.soheila@gmail.com 1003194753284600533 1003194753284600533 Yes Department of Physics, Safadasht Branch, Islamic Azad University, Tehran, Iran Fatemeh Mashayekhi mashayekhi.fatemeh@yahoo.com 1003194753284600534 1003194753284600534 No Department of Physics, Safadasht Branch, Islamic Azad University, Tehran, Iran Amirnader Emami Razavi razavinader@gmail.com 1003194753284600535 1003194753284600535 No Iran National Tumor Bank, Cancer Institute of Iran, Tehran University of Medical Sciences