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Medicinal Plants for Treatment Tauopathy- Recent Advances in Targeting Tau Phosphorylation
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Mohammad Soheil Maveddat   , Banafshe Salehi , Bahareh Salehi , Behdokht Jamali , Koorosh Shahpasand * |
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Abstract: (96 Views) |
| The prevalence of neurodegenerative diseases such as Alzheimer's disease (AD) has increased in recent years and put additional strain on the health systems of most countries. Although great progress has been made in the treatment of these diseases, so far no effective treatment has been found that can block the progression of these diseases. In recent years, there have been reports of inhibition of hyperphosphorylation of Tau protein by extracts or natural compounds derived from medicinal plants. In this review article, we tried to review some of the medicinal plants that have shown these effects in electronic databases. Some medicinal plants including Curcuma longa, Rosmarinus officinalis, Vitis vinifera, Apocynum venetum, Centella asiatica, Rhus succedanea, Maclura pomifera Allium sativum and Ginkgo biloba have been found to show anti-Tau hyperphosphorylation effects and therefore can be considered as adjuvant therapy in Alzheimer disease (AD). The essential oils or natural product of some medicinal plant inhibited the Tau hyperphosphorylation in studies and as results are suitable options in treatments of neurodegenerative diseases including AD. |
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| Keywords: Tau, Hyperphosphorylation, Tauopathy, Alzheimer's disease, Medicinal plant. |
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Full-Text [PDF 261 kb]
(18 Downloads)
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Type of Study: Review |
Subject:
Human Genetics
Received: 2023/12/22 | Accepted: 2024/09/17 | Published: 2023/12/11
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