[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Journal Information::
Instructions for Authors::
Instructions for Reviewers::
Articles archive::
Contact us::
Site Facilities::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
:: Volume 5, Issue 1 (5-2021) ::
jhgg 2021, 5(1): 0-0 Back to browse issues page
A Comprehensive Review on Helicobacter pylori Infection and Gastric Cancer
Farhad Kamandi , Mohammad reza Emadzadeh , Saeed Ghanbari hassan kiadeh , Arefeh Abbasian * , Seyed Amir Hossein Mohammadzadeh Hosseini Moghri
Abstract:   (481 Views)
Background The Helicobacter pylori (H. pylori) is a spiral-shaped, gram-negative, motile and microaerophilic bacterium in which the human stomach is the single natural reservoir.
Objectives This review study indicates the possible contribution of H. pylori infection as one of the recognized vital agents for the development of gastric malignancies.
Methods Journal online databases such as Science Direct, PubMed, Google Scholar, and Wiley Online Library were investigated through keywords “Helicobacter pylori”, “Gastric Malignancy”, “Gene therapy” and “Nanotechnology”. Studies were subjected to the present review study if they met our relevance and quality criteria.
Results We will discuss different virulence elements of H. pylori comprising cytotoxin-related gene A, vacuolating cytotoxin A, as well as various outer membrane proteins leading to malignancy through various mechanisms.
Conclusions We also provide insight into the possible presence and role of a gastric malignancy stem cell in the tumors with the capability to initiate sustain self-renewal and tumor growth and novel strategies against H. pylori such as gene therapy, immunotherapy, immunoinformatics, antibiotic resistance, and nanotechnology aimed to provide a rationale view for new therapeutic approaches that are reviewed in the current study.
Keywords: Gastric Malignancy, Helicobacter pylori, immunoinformatics, Gene therapy, nanotechnology
Full-Text [PDF 595 kb]   (103 Downloads)    
Type of Study: Review | Subject: Human Genetics
Received: 2021/12/13 | Accepted: 2022/04/10 | Published: 2022/12/7
Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Kamandi F, Emadzadeh M R, Ghanbari hassan kiadeh S, Abbasian A, Mohammadzadeh Hosseini Moghri S A H. A Comprehensive Review on Helicobacter pylori Infection and Gastric Cancer. jhgg 2021; 5 (1)
URL: http://humangeneticsgenomics.ir/article-1-42-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 5, Issue 1 (5-2021) Back to browse issues page
Journal of Human Genetics and Genomics Journal of Human Genetics and Genomics
Persian site map - English site map - Created in 0.05 seconds with 36 queries by YEKTAWEB 4652