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:: Volume 4, Issue 2 (12-2020) ::
jhgg 2020, 4(2): 0-0 Back to browse issues page
Extremely Low Frequency Electromagnetic Fields Alter Expression of C-Myc and circ-CCDC66 in Gastric Cancer Cell Line
Abstract:   (196 Views)
The biological effects of electromagnetic fields (EMF), in particular their beneficial or adverse impacts on the promotion and progression of cancer, have attracted considerable attention. C-Myc has a critical regulatory role in cell transformation and causes metabolic changes, that accompany malignant transformation. Observations have shown that c-Myc expression can be altered by circular RNAs (circRNA). In this study, the changes in the expression of c-Myc and circ-CCDC66 in the AGS cell line after the extremely low-frequency magnetic fields (ELF-MF) exposure were investigated. The AGS cells were exposed to different magnetic flux densities for 18 h, continuously and discontinuously (2h on/2h off). To evaluate the expression changes of c-Myc and circ-CCDC66 real-time PCR was used. The results showed that discontinuous magnetic fields could reduce c-Myc expression. Continuous exposure of 0.25
mT could reduce the c-Myc expression, but with increasing the magnetic flux density c-Myc was upregulated. The expression level of circ-CCDC66 decreased under exposure to continuous and discontinuous ELF-MFs. The difference between the results of c-Myc under the influence of magnetic fields may be described by the hypothesis of the window effect of the fields. Our results indicated that ELF-MFs can induce changes in c-Myc and circ-CCDC66 expression.
Full-Text [PDF 378 kb]   (66 Downloads)    
Type of Study: Research | Subject: Human Genetics
Received: 2022/02/12 | Accepted: 2022/03/13 | Published: 2022/04/10
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Extremely Low Frequency Electromagnetic Fields Alter Expression of C-Myc and circ-CCDC66 in Gastric Cancer Cell Line. jhgg 2020; 4 (2)
URL: http://humangeneticsgenomics.ir/article-1-63-en.html


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Volume 4, Issue 2 (12-2020) Back to browse issues page
Journal of Human Genetics and Genomics Journal of Human Genetics and Genomics
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