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:: Volume 6, Issue 1 (5-2022) ::
jhgg 2022, 6(1): 0-0 Back to browse issues page
Curcumin has neuroprotective effects in rotenone-induced Parkinson disease in mice by affecting bcl-2 family gene expressions
Faramarz Khosravi , Vida Hojati , Malihe Entezari * , Mehrdad Hashemi
Abstract:   (198 Views)
Background:  One of the common diseases in different societies is Parkinson's disease (PD), for which no suitable treatment has been found yet. Curcumin a natural compound has shown neuroprotective properties in many studies. Therefore, in this research, the administration of this compound to female mice was studied.
Methods: Induction of PD in mice was done by administering 2 mg rotenone, and then a Rotarod test was performed on female mice. Also, 50 mg/kg of curcumin was administered every day for 21 days and its effects were evaluated in PD mice. Finally, the expression levels of bax and bcl-2 were measured in the brain of female mice by RT-PCR technique. GraphPad Prism V.8 software was used for data analysis.
Results: Induction of PD led to a decrease in the performance of mice in the Rotarod test. However, the administration of curcumin to these mice improved their performance. Also, overexpression of bax and downregulation of bcl-2 genes were observed in the brains of PD mice, to whom the administration of curcumin downregulated bax gene and overexpressed bcl-2 gene.
Conclusion: Curcumin has neuroprotective effects in PD conditions, which can be attributed to the change in expressions of the bcl-2 family gene. More studies are needed in this field.
Keywords: Gene, Curcumin, Neuroprotection, RT-PCR
Full-Text [PDF 608 kb]   (37 Downloads)    
Type of Study: Research | Subject: Gene expression
Received: 2023/02/22 | Accepted: 2023/04/8 | Published: 2023/04/8
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Khosravi F, Hojati V, Entezari M, Hashemi M. Curcumin has neuroprotective effects in rotenone-induced Parkinson disease in mice by affecting bcl-2 family gene expressions. jhgg 2022; 6 (1)
URL: http://humangeneticsgenomics.ir/article-1-79-en.html

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Volume 6, Issue 1 (5-2022) Back to browse issues page
Journal of Human Genetics and Genomics Journal of Human Genetics and Genomics
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