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Curcumin has neuroprotective effects in rotenone-induced Parkinson disease in mice by affecting bcl-2 family gene expressions
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Faramarz Khosravi   , Vida Hojati , Malihe Entezari * , Mehrdad Hashemi |
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Abstract: (196 Views) |
Background: One of the common diseases in different societies is Parkinson's disease (PD), for which no suitable treatment has been found yet. Curcumin a natural compound has shown neuroprotective properties in many studies. Therefore, in this research, the administration of this compound to female mice was studied.
Methods: Induction of PD in mice was done by administering 2 mg rotenone, and then a Rotarod test was performed on female mice. Also, 50 mg/kg of curcumin was administered every day for 21 days and its effects were evaluated in PD mice. Finally, the expression levels of bax and bcl-2 were measured in the brain of female mice by RT-PCR technique. GraphPad Prism V.8 software was used for data analysis.
Results: Induction of PD led to a decrease in the performance of mice in the Rotarod test. However, the administration of curcumin to these mice improved their performance. Also, overexpression of bax and downregulation of bcl-2 genes were observed in the brains of PD mice, to whom the administration of curcumin downregulated bax gene and overexpressed bcl-2 gene.
Conclusion: Curcumin has neuroprotective effects in PD conditions, which can be attributed to the change in expressions of the bcl-2 family gene. More studies are needed in this field. |
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| Keywords: Gene, Curcumin, Neuroprotection, RT-PCR |
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Full-Text [PDF 608 kb]
(37 Downloads)
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Type of Study: Research |
Subject:
Gene expression
Received: 2023/02/22 | Accepted: 2023/04/8 | Published: 2023/04/8
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