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The ANRIL rs4977574 Variant is Associated with Rheumatoid Arthritis Susceptibility
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Ali Karimizadeh   , Mohammad Javad Mokhtari * |
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Abstract: (6 Views) |
Background: As the most common inflammatory arthritis worldwide, rheumatoid arthritis (RA) has been shown in numerous studies to be significantly influenced by long non-coding RNAs (lncRNAs), particularly in terms of disease onset and progression. This research explores the possible association between ANRIL (rs4977574) polymorphisms and susceptibility to RA.
Methods: This study comprised 150 confirmed cases of RA alongside 150 matched healthy controls. Genotyping of DNA was carried out using the tetra-primer amplification refractory mutation system polymerase chain reaction (ARMS-PCR).
Results: Based on multivariate logistic regression, carriers of the AG genotype had a 7.13‑fold higher risk of developing RA compared to those with the AA genotype. Conversely, the GG genotype was associated with a substantial 0.18-fold reduction in RA risk compared to AA. Additionally, the ANRIL rs4977574 variant was shown to increase RA risk across recessive (OR = 1.52, 95% CI = 1.06-2.19, P = 0.022), dominant (OR = 2.49, 95% CI = 1.50-4.13, P = 0.0003), and over-dominant (OR = 8.19, 95% CI = 4.086-16.4, P < 0.0000001) genetic models.
Conclusion: This study established a connection between ANRIL genetic variation and an elevated risk of RA within the Iranian population. |
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| Keywords: Rheumatoid arthritis, ANRIL Long non-coding RNA, Tetra-primer ARMS-PCR, Single Nucleotide Polymorphism |
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Full-Text [PDF 248 kb]
(3 Downloads)
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Type of Study: Research |
Subject:
Human Genetics
Received: 2026/01/5 | Accepted: 2026/06/29 | Published: 2025/05/30
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